ADRB2 gene polymorphism and emphysema heterogeneity can modulate bronchodilator response in patients with emphysema

M Nojiri, S Mizuno, K Nishiki, R Kato… - Pulmonary …, 2018 - Elsevier
… ) gene has been thought to have an important role in the differential response to β 2 -agonist
therapy for asthma… However, previous studies have shown little evidence for an association

The rs2601796 variant in ADCY9 gene is associated with severe asthma and less bronchodilator response

HMP Teixeira, ÁA Cruz, TS Jesus, MBR de Santana… - Gene, 2023 - Elsevier
… Severe asthma patients require treatment with high dose of inhaled … Short-acting
bronchodilators were withheld 6 h prior to … Genetic polymorphisms of the beta-2 andrenergic …

Pharmacogenetics of respiratory disease

IP Hall, SB Liggett - Pharmacogenetics, 2016 - api.taylorfrancis.com
… In this study, the acute bronchodilator response in 121 … the clinical response to repetitive
administration of short-acting … The phosphodiesterase (PDE) 4D subfamily is thought to be the …

Phosphodiesterase 4B inhibition: a potential novel strategy for treating pulmonary fibrosis

M Kolb, B Crestani, TM Maher - European Respiratory Review, 2023 - Eur Respiratory Soc
… sclerosis (SSc)-associated ILD and other chronic fibrosing … stroke [30] and response to
short-acting bronchodilators [31]. … -induced late-asthmatic response and reduced biomarkers of …

Effects of PDE4 gene polymorphisms on efficacy and adverse drug events of ritodrine therapy in preterm labor patients: a prospective observational study

J Yee, HS Hwang, JE Chung, JY Park, KE Lee… - European Journal of …, 2019 - Springer
… PDE4A, 4B, 4C, and 4D mRNA subtypes are present in human … genetic variations and β
agonists among asthma patients by … , showed significant associations with responsiveness of β2 …

Rhinovirus C15 attenuates relaxation and cAMP production in human airways and smooth muscle

EB Gebski, V Parikh, H Lam, N Kim… - American journal of …, 2023 - atsjournals.org
… Additionally, we show that Iso (a short-acting β 2 AR agonist), … study of pediatric patients
with asthma found that the children … Here we sought to examine responses to bronchodilators

SNPs, adipokynes and adiposity in children with asthma

ME Machado, LC Porto, MG Alves Galvão… - … of Asthma, 2023 - Taylor & Francis
… of genetic polymorphisms and adipokines effects in children … pathway, which further
responds by releasing anorexigenic … were not associated with asthma in children (Citation21). …

Pharmacology of the Airways

C Bailey, PJ Wojciechowski, WE Hurford - Principles and Practice of …, 2019 - Springer
… beta-2 adrenergic agonists are administered for the acute relief … beta-2 agonists for asthmatic
patients that are poorly controlled … of more potent bronchodilators such as short-acting beta-…

[HTML][HTML] Phosphodiesterases as therapeutic targets for respiratory diseases

H Zuo, I Cattani-Cavalieri, N Musheshe… - Pharmacology & …, 2019 - Elsevier
… selective PDE inhibitors in the treatment of COPD and asthma. … relies mainly on the use of
bronchodilators (β 2 -adrenoceptor (… the role of PDE3 in an acute house dust mite-driven (HDM-…

Severe asthma

R Wong, FA Maffei - Pediatric Critical Care: Text and Study Guide, 2021 - Springer
… 17q21 strongly associated with childhood-onset asthma. Variation … to repetitive or continuous
administration of short-acting … evaluating levalbuterol and albuterol for acute asthma in all …